9/16/2023 0 Comments Yunfeng liu yu bin![]() It enables valuable supervision for dependency modeling between elements at different positions of the sequence. Position encoding recently has shown effective in the transformer architecture. Jianlin Su, Yu Lu, Shengfeng Pan, Ahmed Murtadha, Bo Wen, Yunfeng Liu. This study identifies a complex responsible for the snRNA 3’ end maturation in plants and uncovers a previously unknown function of CPSF73 in snRNA maturation. RoFormer: Enhanced Transformer with Rotary Position Embedding. ![]() Associate Editor (2013 2018), Journal of Royal Statistical Society, Series B. Associate Editor (2015 present), Journal of Multivariate Analysis. Guest Editor (2018 2019), A special issue for Mathematical Programming, Series B. However, the DSP1 complex does not affect pre-mRNA 3’ end cleavage, suggesting that plants may use different CPSF73-I-containing complexes to process snRNAs and premRNAs. Associate Editor (2019 2022), Canadian Journal of Statistics. The catalytic component of this complex is likely the cleavage and polyadenylation specificity factor 73 kDa-I (CSPF73-I), which is the nuclease cleaving the pre-mRNA 3’ end. We further show that DSP1 forms a conserved complex, which contains at least four additional proteins, to catalyze snRNA 3’ end maturation in Arabidopsis. In addition, DSP1 binds snRNA loci and interacts with Pol-II in a DNA/RNA-dependent manner. A hypomorphic dsp1-1 mutation causes pleiotropic developmental defects, impairs the 3’ end processing of snRNAs, increases the levels of snRNA primary transcripts (pre-snRNAs), and alters the occupancy of Pol II at snRNA loci. ![]() 29 Yeo J C, Yu J, Loh K P, Wang Z and Lim C T 2016 ACS Sensors 1 54351. Here, we show that DEFECTIVE in snRNA PROCESSING 1 (DSP1) is an essential protein for snRNA 3’ end maturation in Arabidopsis. Hongbin An1, Liangzhou Chen1, Xiaojun Liu1, Xiangyang Wang1, Yunfeng Liu1. However, the protein factors responsible for this process remain elusive in plants. The biogenesis of the majority of snRNAs involves 3’ end endonucleolytic cleavage of the nascent transcript from the elongating DNA-dependent RNA ploymerase II. Uridine-rich small nuclear RNAs (snRNAs) are the basal components of the spliceosome and play essential roles in splicing. ![]()
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